Context-dependent EMT programs in cancer metastasis

Epithelial-mesenchymal transition (EMT) is a developmental process whereby stationary, adherent cells acquire the ability to migrate. EMT is critical for dramatic cellular movements during embryogenesis; however, tumor cells can reactivate EMT programs, which increases their aggressiveness. In addition to motility, EMT is associated with enhanced stem cell properties and drug resistance; thus it can drive metastasis, tumor recurrence, and therapy resistance in the context of cancer. However, the precise requirements for EMT in metastasis have not been fully delineated, with different tumor types relying on discrete EMT effectors. Most tumor cells do not undergo a full EMT, but rather adopt some qualities of…

• UD
  U.S. Department of Defense

  Award: BC170055
• BC
  Breast Cancer Research Foundation
• BF
  Brewster Foundation
• SG
  Susan G. Komen
• NI
  National Institutes of Health