Circular RNAs in Cancer: emerging functions in hallmarks, stemness, resistance and roles as potential biomarkers
Central South University · Hunan Cancer Hospital · +1 more institution
Abstract
Circular RNAs (circRNAs) are a class of RNA molecules with closed loops and high stability. CircRNAs are abundantly expressed in eukaryotic organisms and exhibit both location- and step-specificity. In recent years, circRNAs are attracting considerable research attention attributed to their possible contributions to gene regulation through a variety of actions, including sponging microRNAs, interacting with RNA-binding proteins, regulating transcription and splicing, and protein translation. Growing evidence has revealed that circRNAs play critical roles in the development and progression of diseases, especially in cancers. Without doubt, expanding our understanding of circRNAs will enrich knowledge of cancer…
Citation impact
- FWCI
- 32.81
- Percentile
- 100%
- References
- 184
Authors
13- MSMin SuCorresponding
Central South University, Hunan Cancer Hospital
- YXYuhang Xiao
Central South University, Hunan Cancer Hospital, Xiangya Hospital Central South University
- JMJunliang Ma
Central South University, Hunan Cancer Hospital
- YTYanyan Tang
Central South University, Hunan Cancer Hospital
- BTBo Tian
Central South University, Hunan Cancer Hospital
Topics & keywords
- Biology
- microRNA
- Circular RNA
- Computational biology
- Translation (biology)
- Cancer
- RNA
- RNA splicing
- Good health and well-being
Funding
- NNNational Natural Science Foundation of ChinaAward: 81802947
- NSNatural Science Foundation of Hunan ProvinceAwards: 2019JJ50358, 2019JJ50968, 2017JJ2173, 2018JJ3314
- SAScience and Technology Bureau, ChangshaAwards: kq1801110, kq1706045
- HAHealth and Family Planning Commission of Hunan ProvinceAwards: C2019074, B20180545