Two-Dimensional Metal–Organic Framework/Enzyme Hybrid Nanocatalyst as a Benign and Self-Activated Cascade Reagent for in Vivo Wound Healing
University of Science and Technology of China · Chinese Academy of Sciences · +2 more institutions
Abstract
Metal–organic frameworks (MOFs)-based peroxidase mimics have been seldom applied in the biomedical field, especially in vivo. One of the main reasons is their optimum reactions occur in strong acidic environments with a pH of 3–4, severely limiting their applications in living systems where neutral pH is usually required. Other types of peroxidase mimics also suffer such a fatal defect. Additionally, the direct introduction of the relatively high concentrated and toxic reaction reagent H2O2 would induce undesired damage to normal tissues. Herein, a MOF-based hybrid nanocatalyst as a benign and self-activated cascade reagent has been constructed. Owing to better catalytic performance compared with…
Citation impact
- FWCI
- 23.03
- Percentile
- 100%
- References
- 51
Authors
7- XLXinping Liu
University of Science and Technology of China, Chinese Academy of Sciences, Changchun Institute of Applied Chemistry
- ZYZhengqing Yan
Chinese Academy of Sciences, Changchun Institute of Applied Chemistry, University of Chinese Academy of Sciences
- YZYan Zhang
Chinese Academy of Sciences, Changchun Institute of Applied Chemistry, University of Chinese Academy of Sciences
- ZLZhengwei Liu
Chinese Academy of Sciences, Changchun Institute of Applied Chemistry, University of Chinese Academy of Sciences
- YSYuhuan Sun
University of Science and Technology of China, Chinese Academy of Sciences, Changchun Institute of Applied Chemistry
Topics & keywords
- Gluconic acid
- Reagent
- Glucose oxidase
- Nanosheet
- Catalysis
- Chemistry
- Peroxidase
- In vivo