Genome-wide association meta-analysis of 78,308 individuals identifies new loci and genes influencing human intelligence

Sniekers, Suzanne; Stringer, Sven; Watanabe, Kyoko; Jansen, Philip R.; Coleman, Jonathan R. I.; Krapohl, Eva; Taskesen, Erdogan; Hammerschlag, Anke R.; Okbay, Aysu; Zabaneh, Delilah; Amin, Najaf; Breen, Gerome; Cesarini, David; Chabris, Christopher F.; Iacono, William G.; Ikram, M. Arfan; Johannesson, Magnus; Koellinger, Philipp; Lee, James J.; Magnusson, Patrik K. E.; McGue, Matt; Miller, Mike; Ollier, William; Payton, Antony; Pendleton, Neil; Plomin, Robert; Rietveld, Cornelius A.; Tiemeier, Henning; Duijn, Cornelia M. van; Posthuma, Daniëlle

doi:10.1038/ng.3869

reviewNature GeneticsMay 22, 2017HYBRID OA

Genome-wide association meta-analysis of 78,308 individuals identifies new loci and genes influencing human intelligence

SSSuzanne Sniekers SSSven Stringer KWKyoko Watanabe PRPhilip R. Jansen JRJonathan R. I. Coleman

Amsterdam Neuroscience · Erasmus MC · +12 more institutions

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Abstract

Danielle Posthuma and colleagues perform a large meta-analysis for intelligence and determine genetic overlap with several neuropsychiatric and metabolic traits. They find 15 new significant loci and implicate 40 new genes, most of which are predominantly expressed in the brain. Intelligence is associated with important economic and health-related life outcomes1. Despite intelligence having substantial heritability2 (0.54) and a confirmed polygenic nature, initial genetic studies were mostly underpowered3,4,5. Here we report a meta-analysis for intelligence of 78,308 individuals. We identify 336 associated SNPs (METAL P

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Keywords

Biology
Heritability
Genetic architecture
Gene
Genetics
Single-nucleotide polymorphism
Genome-wide association study
Genetic association

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