articleScience AdvancesApr 5, 2019GOLD OA

A pan-coronavirus fusion inhibitor targeting the HR1 domain of human coronavirus spike

SXShuai XiaLYLei YanWXWei XuASAnurodh Shankar AgrawalAAAbdullah Algaissi

Shanghai Medical College of Fudan University · Shanghai Public Health Clinical Center · +6 more institutions

PubMed
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Abstract

Continuously emerging highly pathogenic human coronaviruses (HCoVs) remain a major threat to human health, as illustrated in past SARS-CoV and MERS-CoV outbreaks. The development of a drug with broad-spectrum HCoV inhibitory activity would address this urgent unmet medical need. Although previous studies have suggested that the HR1 of HCoV spike (S) protein is an important target site for inhibition against specific HCoVs, whether this conserved region could serve as a target for the development of broad-spectrum pan-CoV inhibitor remains controversial. Here, we found that peptide OC43-HR2P, derived from the HR2 domain of HCoV-OC43, exhibited broad fusion inhibitory activity against multiple HCoVs. EK1, the…

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525
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13

Topics & keywords

Topics
Keywords
  • Coronavirus
  • Virology
  • Coronavirus disease 2019 (COVID-19)
  • Spike (software development)
  • Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)
  • 2019-20 coronavirus outbreak
  • Fusion
  • Coronavirus Infections
UN Sustainable Development Goals
  • Good health and well-being
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