Mettl3-mediated mRNA m6A methylation promotes dendritic cell activation
Second Military Medical University · Chinese Academy of Medical Sciences & Peking Union Medical College · +6 more institutions
Abstract
Abstract N6-methyladenosine (m 6 A) modification plays important roles in various cellular responses by regulating mRNA biology. However, how m 6 A modification is involved in innate immunity via affecting the translation of immune transcripts remains to be further investigated. Here we report that RNA methyltransferase Mettl3-mediated mRNA m 6 A methylation promotes dendritic cell (DC) activation and function. Specific depletion of Mettl3 in DC resulted in impaired phenotypic and functional maturation of DC, with decreased expression of co-stimulatory molecules CD40, CD80 and cytokine IL-12, and reduced ability to stimulate T cell responses both in vitro and in vivo. Mechanistically, Mettl3-mediated m 6 A of…
Citation impact
- FWCI
- 21.53
- Percentile
- 100%
- References
- 60
Authors
8- HWHuamin WangCorresponding
Second Military Medical University, Chinese Academy of Medical Sciences & Peking Union Medical College, Nankai University
- XHXiang Hu
Second Military Medical University, Chinese Academy of Medical Sciences & Peking Union Medical College, Zhejiang University
- MHMingyan Huang
Second Military Medical University
- JLJuan Liu
Second Military Medical University
- YGYan Gu
Second Military Medical University
Topics & keywords
- CD80
- Cell biology
- Dendritic cell
- CD86
- Translation (biology)
- Biology
- Messenger RNA
- T cell