The Major Risk Factors for Alzheimer’s Disease: Age, Sex, and Genes Modulate the Microglia Response to Aβ Plaques
UK Dementia Research Institute · VIB-KU Leuven Center for Brain & Disease Research · +8 more institutions
Abstract
Mice over time demonstrate that progressive amyloid-β accumulation accelerates two main activated microglia states that are also present during normal aging. Activated response microglia (ARMs) are composed of specialized subgroups overexpressing MHC type II and putative tissue repair genes (Dkk2, Gpnmb, and Spp1) and are strongly enriched with Alzheimer's disease (AD) risk genes. Microglia from female mice progress faster in this activation trajectory. Similar activated states are also found in a second AD model and in human brain. Apoe, the major genetic risk factor for AD, regulates the ARMs but not the interferon response microglia (IRMs). Thus, the ARMs response is the converging point for aging, sex, and…
Citation impact
- FWCI
- 42.99
- Percentile
- 100%
- References
- 83
Authors
19- CSCarlo Sala FrigerioCorresponding
UK Dementia Research Institute, VIB-KU Leuven Center for Brain & Disease Research, University College London, KU Leuven
- LWLeen Wolfs
VIB-KU Leuven Center for Brain & Disease Research, KU Leuven
- NFNicola Fattorelli
VIB-KU Leuven Center for Brain & Disease Research, KU Leuven
- NTNicola Thrupp
VIB-KU Leuven Center for Brain & Disease Research, KU Leuven
- IVIryna Voytyuk
VIB-KU Leuven Center for Brain & Disease Research, KU Leuven
Topics & keywords
- Microglia
- Disease
- Gene
- Alzheimer's disease
- Medicine
- Biology
- Gerontology
- Genetics
- Good health and well-being