Inflammasomes in neuroinflammatory and neurodegenerative diseases
Ghent University · VIB-UGent Center for Inflammation Research · +3 more institutions
Abstract
Neuroinflammation and neurodegeneration often result from the aberrant deposition of aggregated host proteins, including amyloid-β, α-synuclein, and prions, that can activate inflammasomes. Inflammasomes function as intracellular sensors of both microbial pathogens and foreign as well as host-derived danger signals. Upon activation, they induce an innate immune response by secreting the inflammatory cytokines interleukin (IL)-1β and IL-18, and additionally by inducing pyroptosis, a lytic cell death mode that releases additional inflammatory mediators. Microglia are the prominent innate immune cells in the brain for inflammasome activation. However, additional CNS-resident cell types including astrocytes and…
Citation impact
- FWCI
- 28.71
- Percentile
- 100%
- References
- 168
Authors
4- SVSofie VoetCorresponding
Ghent University, VIB-UGent Center for Inflammation Research
- SSSahana Srinivasan
Ghent University, VIB-UGent Center for Inflammation Research
- MLMohamed Lamkanfi
Johnson & Johnson (United States), Janssen (Belgium), Ghent University, VIB-UGent Center for Inflammation Research, Johnson & Johnson (Brazil)
- GLGeert Loo
Ghent University, VIB-UGent Center for Inflammation Research
Topics & keywords
- Neuroinflammation
- Microglia
- Neurodegeneration
- Medicine
- Neuroscience
- Amyotrophic lateral sclerosis
- Immunology
- Inflammation
- Good health and well-being