The emerging roles and functions of circular RNAs and their generation

Circular RNAs (circRNAs) are closed long non-coding RNAs, in which the 5' and 3' termini are covalently linked by back-splicing of exons from a single pre-mRNA. Emerging evidence indicates that circRNAs are broadly expressed in mammalian cells and show cell type- or tissue-specific expression patterns. Importantly, circRNAs have been shown to participate in regulating various biological processes. Functionally, circRNAs can influence cellular physiology through various molecular mechanisms, such as serving as a decoy for microRNAs or RNA-binding proteins to modulate gene expression or translation of regulatory proteins. The biogenesis of circRNAs is known to be tightly regulated by cis- (intronic complementary…

• AS
  Academia Sinica

  Awards: MOST 105-0210-01-13-01, AS-104-TP-B09, 105-0210-01-13-01, 104-0210-01-09-02, MOST 104-0210-01-09-02, AS-103-TP-B10
• MO
  Ministry of Science and Technology, Taiwan

  Awards: MOST 104-0210-01-09-02, MOST-106-2321-B-194-001-MY3, MOST106-0210-01-15-02, MOST 105-0210-01-13-01