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RETRACTED ARTICLE: RNA m6A methylation regulates the epithelial mesenchymal transition of cancer cells and translation of Snail
Sun Yat-sen University · University of Chicago · +2 more institutions
Abstract
Abstract N6 -Methyladenosine (m 6 A) modification has been implicated in the progression of several cancers. We reveal that during epithelial-mesenchymal transition (EMT), one important step for cancer cell metastasis, m 6 A modification of mRNAs increases in cancer cells. Deletion of methyltransferase-like 3 (METTL3) down-regulates m 6 A, impairs the migration, invasion and EMT of cancer cells both in vitro and in vivo. m 6 A-sequencing and functional studies confirm that Snail, a key transcription factor of EMT, is involved in m 6 A-regulated EMT. m 6 A in Snail CDS, but not 3’UTR, triggers polysome-mediated translation of Snail mRNA in cancer cells. Loss and gain functional studies confirm that YTHDF1…
Citation impact
- FWCI
- 31.19
- Percentile
- 100%
- References
- 69
Authors
12Topics & keywords
- Snail
- Epithelial–mesenchymal transition
- Polysome
- Downregulation and upregulation
- N6-Methyladenosine
- Translation (biology)
- Cancer research
- Biology