An overview of active and passive targeting strategies to improve the nanocarriers efficiency to tumour sites
National Research Centre · Université de Strasbourg · +2 more institutions
Abstract
OBJECTIVES: This review highlights both the physicochemical characteristics of the nanocarriers (NCs) and the physiological features of tumour microenvironment (TME) to outline what strategies undertaken to deliver the molecules of interest specifically to certain lesions. This review discusses these properties describing the convenient choice between passive and active targeting mechanisms with details, illustrated with examples of targeting agents up to preclinical research or clinical advances. KEY FINDINGS: Targeted delivery approaches for anticancers have shown a steep rise over the past few decades. Though many successful preclinical trials, only few passive targeted nanocarriers are approved for…
Citation impact
- FWCI
- 33.50
- Percentile
- 100%
- References
- 136
Authors
5Topics & keywords
- Nanocarriers
- Targeted drug delivery
- Medicine
- Targeted therapy
- Cancer research
- Nanotechnology
- Computational biology
- Pharmacology