Lipopolysaccharide-Induced Neuroinflammation as a Bridge to Understand Neurodegeneration

A large body of experimental evidence suggests that neuroinflammation is a key pathological event triggering and perpetuating the neurodegenerative process associated with many neurological diseases. Therefore, different stimuli, such as lipopolysaccharide (LPS), are used to model neuroinflammation associated with neurodegeneration. By acting at its receptors, LPS activates various intracellular molecules, which alter the expression of a plethora of inflammatory mediators. These factors, in turn, initiate or contribute to the development of neurodegenerative processes. Therefore, LPS is an important tool for the study of neuroinflammation associated with neurodegenerative diseases. However, the serotype, route…

• CN
  Conselho Nacional de Desenvolvimento Científico e Tecnológico

  Awards: CNPq - 424588/2016-1, CNPq - 309718/2015-5
• FD
  Fundação de Amparo à Pesquisa do Estado de Minas Gerais

  Award: CBB-APQ-02044-15