Adipose Tissue Dysfunction as Determinant of Obesity-Associated Metabolic Complications
Federico II University Hospital · Institute for Experimental Endocrinology and Oncology · +2 more institutions
Abstract
Obesity is a critical risk factor for the development of type 2 diabetes (T2D), and its prevalence is rising worldwide. White adipose tissue (WAT) has a crucial role in regulating systemic energy homeostasis. Adipose tissue expands by a combination of an increase in adipocyte size (hypertrophy) and number (hyperplasia). The recruitment and differentiation of adipose precursor cells in the subcutaneous adipose tissue (SAT), rather than merely inflating the cells, would be protective from the obesity-associated metabolic complications. In metabolically unhealthy obesity, the storage capacity of SAT, the largest WAT depot, is limited, and further caloric overload leads to the fat accumulation in ectopic tissues…
Citation impact
- FWCI
- 81.98
- Percentile
- 100%
- References
- 184
Authors
8- MLMichele Longo
Federico II University Hospital, Institute for Experimental Endocrinology and Oncology, National Research Council, University of Naples Federico II
- FZFederica Zatterale
Federico II University Hospital, Institute for Experimental Endocrinology and Oncology, National Research Council, University of Naples Federico II
- JNJamal Naderi
Federico II University Hospital, Institute for Experimental Endocrinology and Oncology, National Research Council, University of Naples Federico II
- LPLuca Parrillo
Federico II University Hospital, Institute for Experimental Endocrinology and Oncology, National Research Council, University of Naples Federico II
- PFPietro Formisano
Federico II University Hospital, Institute for Experimental Endocrinology and Oncology, National Research Council, University of Naples Federico II
Topics & keywords
- Adipose tissue
- Lipotoxicity
- Endocrinology
- Internal medicine
- Insulin resistance
- Overnutrition
- White adipose tissue
- Adipocyte
- Zero hunger