reviewAdvanced Healthcare MaterialsMay 8, 2019Closed access

Photosensitizers for Photodynamic Therapy

MLMinhuan LanSZShaojing ZhaoWLWeimin LiuCLChun‐Sing LeeWZWenjun Zhang

Central South University · Chinese Academy of Sciences · +2 more institutions

PubMed
Indexed incrossrefpubmed

Abstract

Abstract As an emerging clinical modality for cancer treatment, photodynamic therapy (PDT) takes advantage of the cytotoxic activity of reactive oxygen species (ROS) that are generated by light irradiating photosensitizers (PSs) in the presence of oxygen (O 2 ). However, further advancements including tumor selectivity and ROS generation efficiency are still required. Substantial efforts are devoted to design and synthesize smart PSs with optimized properties for achieving a desirable therapeutic efficacy. This review summarizes the recent progress in developing intelligent PSs for efficient PDT, ranging from single molecules to delicate nanomaterials. The strategies to improve ROS generation through…

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1,040
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43.55
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100%
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247
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Authors

6

Topics & keywords

Topics
Keywords
  • Photodynamic therapy
  • Photothermal therapy
  • Reactive oxygen species
  • Cancer therapy
  • Radiation therapy
  • Nanotechnology
  • Cancer treatment
  • Cancer
UN Sustainable Development Goals
  • Affordable and clean energy
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