Stem Cell-Derived Exosomes as Nanotherapeutics for Autoimmune and Neurodegenerative Disorders
University of California, Irvine · Edwards Lifesciences (United States) · +4 more institutions
Abstract
To dissect therapeutic mechanisms of transplanted stem cells and develop exosome-based nanotherapeutics in treating autoimmune and neurodegenerative diseases, we assessed the effect of exosomes secreted from human mesenchymal stem cells (MSCs) in treating multiple sclerosis using an experimental autoimmune encephalomyelitis (EAE) mouse model. We found that intravenous administration of exosomes produced by MSCs stimulated by IFNγ (IFNγ-Exo) (i) reduced the mean clinical score of EAE mice compared to PBS control, (ii) reduced demyelination, (iii) decreased neuroinflammation, and (iv) upregulated the number of CD4+CD25+FOXP3+ regulatory T cells (Tregs) within the spinal cords of EAE mice. Co-culture of IFNγ-Exo…
Citation impact
- FWCI
- 22.90
- Percentile
- 100%
- References
- 99
Authors
21- MRMilad Riazifar
University of California, Irvine, Edwards Lifesciences (United States)
- MRM. Rezaa Mohammadi
University of California, Irvine
- EJEgest J. Pone
University of California, Irvine, Edwards Lifesciences (United States)
- AYAshish Yeri
Translational Genomics Research Institute
- CLCecilia Lässer
University of Gothenburg
Topics & keywords
- Experimental autoimmune encephalomyelitis
- Microvesicles
- FOXP3
- Mesenchymal stem cell
- Immune system
- Exosome
- Immunology
- Multiple sclerosis
- Good health and well-being