Fluorine‐Containing Drugs Approved by the FDA in 2018
Nanjing Forestry University · Universitat de València · +4 more institutions
Abstract
Abstract Over the last two decades, fluorine substitution has become one of the essential structural traits in modern pharmaceuticals. Thus, about half of the most successful drugs (blockbuster drugs) contain fluorine atoms. In this review, we profile 17 fluorine‐containing drugs approved by the food and drug administration (FDA) in 2018. The newly approved pharmaceuticals feature several types of aromatic F and CF 3 , as well as aliphatic (CF 2 ) substitution, offering advances in the treatment of various diseases, including cancer, HIV, malarial and smallpox infections.
Citation impact
- FWCI
- 26.50
- Percentile
- 100%
- References
- 120
Authors
8- HMHaibo Mei
Nanjing Forestry University
- JHJianlin HanCorresponding
Nanjing Forestry University
- SFSantos FusteroCorresponding
Universitat de València, Centro de Investigacion Principe Felipe
- MMMercedes Medio‐Simón
Universitat de València, Centro de Investigacion Principe Felipe
- DMDaniel M. Sedgwick
Universitat de València, Centro de Investigacion Principe Felipe
Topics & keywords
- Food and drug administration
- Drug
- Approved drug
- Human immunodeficiency virus (HIV)
- Pharmacology
- Medicine
- Virology
- Good health and well-being