Molecular Mechanisms Responsible for Therapeutic Potential of Mesenchymal Stem Cell-Derived Secretome

Mesenchymal stem cell (MSC)-sourced secretome, defined as the set of MSC-derived bioactive factors (soluble proteins, nucleic acids, lipids and extracellular vesicles), showed therapeutic effects similar to those observed after transplantation of MSCs. MSC-derived secretome may bypass many side effects of MSC-based therapy, including unwanted differentiation of engrafted MSCs. In contrast to MSCs which had to be expanded in culture to reach optimal cell number for transplantation, MSC-sourced secretome is immediately available for treatment of acute conditions, including fulminant hepatitis, cerebral ischemia and myocardial infarction. Additionally, MSC-derived secretome could be massively produced from…

• NF
  Novartis Foundation

  Awards: 16C197, MP01/18, ON175103, ON175069
• MP
  Ministarstvo Prosvete, Nauke i Tehnološkog Razvoja

  Award: ON175069, ON175103
• NS
  Novartis Stiftung für Medizinisch-Biologische Forschung

  Award: 16C197
• FM
  Fakultet Medicinskih Nauka, Univerziteta U Kragujevcu

  Awards: 16C197, MP01/18, ON175069, ON175103