Microstructural and functional gradients are increasingly dissociated in transmodal cortices

While the role of cortical microstructure in organising neural function is well established, it remains unclear how structural constraints can give rise to more flexible elements of cognition. While nonhuman primate research has demonstrated a close structure-function correspondence, the relationship between microstructure and function remains poorly understood in humans, in part because of the reliance on post mortem analyses, which cannot be directly related to functional data. To overcome this barrier, we developed a novel approach to model the similarity of microstructural profiles sampled in the direction of cortical columns. Our approach was initially formulated based on an ultra-high-resolution 3D…

• G
  GlaxoSmithKline
• SF
  Savoy Foundation
• NI
  National Institute for Health and Care Research
• UO
  University of Cambridge
• HF
  Hospital for Sick Children
• NI
  National Institutes of Health
• CI
  Canadian Institutes of Health Research

  Awards: 154298, FDN-154298
• NS
  Natural Sciences and Engineering Research Council of Canada

  Awards: Discovery-1304413, 1304413
• FD
  Fonds de Recherche du Québec - Santé

  Awards: 1304413, FDN-154298, Junior 1
• CA
  Centre Azrieli de recherche sur l'autisme, Institut et Hôpital Neurologiques de Montréal