Hypervirulent Klebsiella pneumoniae

(cKp). hvKp usually infects individuals from the community, who are often healthy. Infections are more common in the Asian Pacific Rim but are occurring globally. hvKp infection frequently presents at multiple sites or subsequently metastatically spreads, often requiring source control. hvKp has an increased ability to cause central nervous system infection and endophthalmitis, which require rapid recognition and site-specific treatment. The genetic factors that confer hvKp's hypervirulent phenotype are present on a large virulence plasmid and perhaps integrative conjugal elements. Increased capsule production and aerobactin production are established hvKp-specific virulence factors. Similar to cKp, hvKp…

• UD
  U.S. Department of Veterans Affairs

  Award: 1I01BX000984
• NI
  National Institute of Allergy and Infectious Diseases

  Awards: 1R21AI088318, 1R21AI123558