A Comprehensive Review on Current Advances in Peptide Drug Development and Design
Chang Gung University · QIMR Berghofer Medical Research Institute · +1 more institution
Abstract
Protein-protein interactions (PPIs) execute many fundamental cellular functions and have served as prime drug targets over the last two decades. Interfering intracellular PPIs with small molecules has been extremely difficult for larger or flat binding sites, as antibodies cannot cross the cell membrane to reach such target sites. In recent years, peptides smaller size and balance of conformational rigidity and flexibility have made them promising candidates for targeting challenging binding interfaces with satisfactory binding affinity and specificity. Deciphering and characterizing peptide-protein recognition mechanisms is thus central for the invention of peptide-based strategies to interfere with…
Citation impact
- FWCI
- 64.30
- Percentile
- 100%
- References
- 118
Authors
4- ACAndy Chi-Lung Lee
Chang Gung University, QIMR Berghofer Medical Research Institute, Chang Gung Memorial Hospital
- JLJanelle L. Harris
QIMR Berghofer Medical Research Institute
- KKKum Kum Khanna
QIMR Berghofer Medical Research Institute
- JHJi‐Hong HongCorresponding
Chang Gung University, Chang Gung Memorial Hospital
Topics & keywords
- Peptide
- Docking (animal)
- Computational biology
- Peptidomimetic
- Drug development
- Drug discovery
- Protein–protein interaction
- Drug