reviewFrontiers in ImmunologyMay 14, 2019GOLD OA

L-selectin: A Major Regulator of Leukocyte Adhesion, Migration and Signaling

AÍAleksandar ÍveticHLHannah L.H. GreenSJSamuel James Hart

King's College London

PubMed
Indexed incrossrefdoajpubmed

Abstract

L-selectin (CD62L) is a type-I transmembrane glycoprotein and cell adhesion molecule that is expressed on most circulating leukocytes. Since its identification in 1983, L-selectin has been extensively characterised as a tethering/rolling receptor. There is now mounting evidence in the literature to suggest that L-selectin plays a role in regulating monocyte protrusion during transendothelial migration (TEM). The N-terminal calcium-dependent (C-type) lectin domain of L-selectin interacts with numerous glycans, including sialyl Lewis X (sLex) for tethering/rolling and proteoglycans for TEM. Although the signals downstream of L-selectin-dependent adhesion are poorly understood, they will invariably involve the…

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Authors

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Topics & keywords

Topics
Keywords
  • Cell biology
  • Selectin
  • Moesin
  • Ectodomain
  • Cell adhesion
  • Ezrin
  • Cell adhesion molecule
  • Adhesion
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