An Atlas of Vagal Sensory Neurons and Their Molecular Specialization

Sensory functions of the vagus nerve are critical for conscious perceptions and for monitoring visceral functions in the cardio-pulmonary and gastrointestinal systems. Here, we present a comprehensive identification, classification, and validation of the neuron types in the neural crest (jugular) and placode (nodose) derived vagal ganglia by single-cell RNA sequencing (scRNA-seq) transcriptomic analysis. Our results reveal major differences between neurons derived from different embryonic origins. Jugular neurons exhibit fundamental similarities to the somatosensory spinal neurons, including major types, such as C-low threshold mechanoreceptors (C-LTMRs), A-LTMRs, Aδ-nociceptors, and cold-, and mechano-heat…

• WT
  Wellcome Trust
• H
  Hjärnfonden

  Award: FO2017-0075
• KI
  Karolinska Institutet
• KO
  Knut och Alice Wallenbergs Stiftelse
• SJ
  Sigrid Juséliuksen Säätiö
• MF
  Medicinska Forskningsrådet
• SF
  Science for Life Laboratory
• ER
  European Research Council

  Award: 740491
• H2
  Horizon 2020