reviewMaterials Today BioJan 1, 2019GOLD OA

Bioinks and bioprinting technologies to make heterogeneous and biomimetic tissue constructs

University of Oulu · University of California, Los Angeles · +2 more institutions

PubMed
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Abstract

The native tissues are complex structures consisting of different cell types, extracellular matrix materials, and biomolecules. Traditional tissue engineering strategies have not been able to fully reproduce biomimetic and heterogeneous tissue constructs because of the lack of appropriate biomaterials and technologies. However, recently developed three-dimensional bioprinting techniques can be leveraged to produce biomimetic and complex tissue structures. To achieve this, multicomponent bioinks composed of multiple biomaterials (natural, synthetic, or hybrid natural-synthetic biomaterials), different types of cells, and soluble factors have been developed. In addition, advanced bioprinting technologies have…

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