A strongly adhesive hemostatic hydrogel for the repair of arterial and heart bleeds
Second Affiliated Hospital of Zhejiang University · Zhejiang University-University of Edinburgh Institute · +5 more institutions
Abstract
Uncontrollable bleeding is a major problem in surgical procedures and after major trauma. Existing hemostatic agents poorly control hemorrhaging from traumatic arterial and cardiac wounds because of their weak adhesion to wet and mobile tissues. Here we design a photo-reactive adhesive that mimics the extracellular matrix (ECM) composition. This biomacromolecule-based matrix hydrogel can undergo rapid gelling and fixation to adhere and seal bleeding arteries and cardiac walls after UV light irradiation. These repairs can withstand up to 290 mm Hg blood pressure, significantly higher than blood pressures in most clinical settings (systolic BP 60-160 mm Hg). Most importantly, the hydrogel can stop high-pressure…
Citation impact
- FWCI
- 58.81
- Percentile
- 100%
- References
- 34
Authors
17- YHYi HongCorresponding
Second Affiliated Hospital of Zhejiang University, Zhejiang University-University of Edinburgh Institute, Zhejiang University
- FZFeifei Zhou
Second Affiliated Hospital of Zhejiang University, Zhejiang University-University of Edinburgh Institute, Zhejiang University
- YHYujie Hua
East China University of Science and Technology
- XZXianzhu Zhang
Second Affiliated Hospital of Zhejiang University, Zhejiang University-University of Edinburgh Institute, Zhejiang University
- CNChengyao Ni
First Affiliated Hospital Zhejiang University, Zhejiang University
Topics & keywords
- Hemostasis
- Adhesive
- Medicine
- Cardiology
- Surgery
- Materials science
- Nanotechnology
- Good health and well-being