Mechanistic Insights into the Antimicrobial Actions of Metallic Nanoparticles and Their Implications for Multidrug Resistance
Yeungnam University · Amity University · +2 more institutions
Abstract
Multiple drug-resistant bacteria are a severe and growing public health concern. Because relatively few antibiotics have been approved over recent years and because of the inability of existing antibiotics to combat bacterial infections fully, demand for unconventional biocides is intense. Metallic nanoparticles (NPs) offer a novel potential means of fighting bacteria. Although metallic NPs exert their effects through membrane protein damage, superoxide radicals and the generation of ions that interfere with the cell granules leading to the formation of condensed particles, their antimicrobial potential, and mechanisms of action are still debated. This article discusses the action of metallic NPs as…
Citation impact
- FWCI
- 20.56
- Percentile
- 100%
- References
- 99
Authors
7Topics & keywords
- Antibiotics
- Antimicrobial
- Biocide
- Bacteria
- Antibiotic resistance
- Multiple drug resistance
- Bacterial cell structure
- Drug
- Good health and well-being