Advances in therapeutic applications of extracellular vesicles
Karolinska Institutet · PsiOxus Therapeutics (United Kingdom) · +5 more institutions
Abstract
Extracellular vesicles (EVs) are nanometer-sized, lipid membrane-enclosed vesicles secreted by most, if not all, cells and contain lipids, proteins, and various nucleic acid species of the source cell. EVs act as important mediators of intercellular communication that influence both physiological and pathological conditions. Given their ability to transfer bioactive components and surmount biological barriers, EVs are increasingly being explored as potential therapeutic agents. EVs can potentiate tissue regeneration, participate in immune modulation, and function as potential alternatives to stem cell therapy, and bioengineered EVs can act as delivery vehicles for therapeutic agents. Here, we cover recent…
Citation impact
- FWCI
- 41.36
- Percentile
- 100%
- References
- 183
Authors
5- OPOscar P. B. WiklanderCorresponding
Karolinska Institutet, PsiOxus Therapeutics (United Kingdom)
- MÁMeadhbh Á. Brennan
Harvard University, Inserm, Massachusetts General Hospital, Nantes Université
- JLJan Lötvall
University of Gothenburg
- XOXandra O. Breakefield
Massachusetts General Hospital
- SESamir EL AndaloussiCorresponding
Karolinska Institutet, PsiOxus Therapeutics (United Kingdom)
Topics & keywords
- Extracellular vesicles
- Extracellular vesicle
- Extracellular
- Vesicle
- Cell biology
- Microvesicles
- Chemistry
- Biology