Early Time-Restricted Feeding Improves 24-Hour Glucose Levels and Affects Markers of the Circadian Clock, Aging, and Autophagy in Humans

Time-restricted feeding (TRF) is a form of intermittent fasting that involves having a longer daily fasting period. Preliminary studies report that TRF improves cardiometabolic health in rodents and humans. Here, we performed the first study to determine how TRF affects gene expression, circulating hormones, and diurnal patterns in cardiometabolic risk factors in humans. Eleven overweight adults participated in a 4-day randomized crossover study where they ate between 8 am and 2 pm (early TRF (eTRF)) and between 8 am and 8 pm (control schedule). Participants underwent continuous glucose monitoring, and blood was drawn to assess cardiometabolic risk factors, hormones, and gene expression in whole blood cells.…

• OS
  Obesity Society
• UO
  University of Alabama at Birmingham
• UO
  University of Alabama
• NI
  National Institute of General Medical Sciences

  Award: U54 GM104940
• NI
  National Institute of Diabetes and Digestive and Kidney Diseases

  Award: P30 DK072476
• NC
  National Center for Advancing Translational Sciences

  Award: KL2 TR001419