Multi-omics of the gut microbial ecosystem in inflammatory bowel diseases

Inflammatory bowel diseases, which include Crohn's disease and ulcerative colitis, affect several million individuals worldwide. Crohn's disease and ulcerative colitis are complex diseases that are heterogeneous at the clinical, immunological, molecular, genetic, and microbial levels. Individual contributing factors have been the focus of extensive research. As part of the Integrative Human Microbiome Project (HMP2 or iHMP), we followed 132 subjects for one year each to generate integrated longitudinal molecular profiles of host and microbial activity during disease (up to 24 time points each; in total 2,965 stool, biopsy, and blood specimens). Here we present the results, which provide a comprehensive view of…

• NS
  National Science Foundation

  Awards: 1053486, DE-AC05-76RL01830, 76RL01830, DBI-1053486
• UD
  U.S. Department of Energy

  Awards: 76RL01830, AC05-76RL01830, DE-AC05-76RL01830, DE-AC05
• B
  Battelle

  Awards: AC05-76RL01830, DE-AC05, DE-AC05-76RL01830
• LM
  Leona M. and Harry B. Helmsley Charitable Trust

  Awards: P01DK046763, U01DK062413
• HT
  Harvard T.H. Chan School of Public Health
• CA
  Crohn's and Colitis Foundation
• BI
  Broad Institute
• V
  Vetenskapsrådet

  Award: 4.1-2016-00416
• NI
  National Institutes of Health

  Awards: U54DE023798, P01DK046763, UL1TR001881, DBI-1053486, R24DK110499, U54DK102557, U01DK062413, R01HG005969, P30DK043351, DE-AC05-76RL01830
• AR
  Army Research Office

  Awards: W911NF-11-1-0473, W911NF, W911NF-11
• PN
  Pacific Northwest National Laboratory

  Awards: DE-AC05-76RL01830, 76RL01830