Effect of tumor microenvironment on pathogenesis of the head and neck squamous cell carcinoma: a systematic review

The tumor microenvironment (TME) is comprised of many different cell populations, such as cancer-associated fibroblasts and various infiltrating immune cells, and non-cell components of extracellular matrix. These crucial parts of the surrounding stroma can function as both positive and negative regulators of all hallmarks of cancer development, including evasion of apoptosis, induction of angiogenesis, deregulation of the energy metabolism, resistance to the immune detection and destruction, and activation of invasion and metastasis. This review represents a summary of recent studies focusing on describing these effects of microenvironment on initiation and progression of the head and neck squamous cell…

• MŠ
  Ministerstvo Školství, Mládeže a Tělovýchovy

  Awards: CZ.02.1.01/0.0/0.0/16_019, CZ.02.1.01/0.0/0.0/16_019/0000785, MUNI/A/1297/2017, CZ.02.1.01/0.0/0.0/16_019/, CZ.02.1.01
• GA
  Grantová Agentura České Republiky

  Awards: CZ.02.1.01/0.0, 18-03978S, CZ.02.1.01, CZ.02.1.01/0.0/0.0/16_019/0000785
• MZ
  Ministerstvo Zdravotnictví Ceské Republiky

  Awards: CZ.02.1.01/0.0, NV18-08-00229
• MU
  Masarykova Univerzita
• LF
  Lékařská fakulta, Masarykova univerzita