Duration of preclinical, prodromal, and dementia stages of Alzheimer's disease in relation to age, sex, and  APOE  genotype

Vermunt, Lisa; Sikkes, Sietske A.M.; Hout, Ardo van den; Handels, Ron; Bos, Isabelle; Flier, Wiesje M. van der; Kern, Silke; Ousset, Pierre‐Jean; Maruff, Paul; Skoog, Ingmar; Verhey, Frans R.J.; Freund‐Levi, Yvonne; Tsolaki, Magda; Wallin, Åsa K.; Rikkert, Marcel G. M. Olde; Soininen, Hilkka; Spiru, L.; Zetterberg, Henrik; Blennow, Kaj; Scheltens, Philip; Muñiz‐Terrera, Graciela; Visser, Pieter Jelle; Initiative, for the Alzheimer Disease Neuroimaging; groups, ICTUS/DSA study

doi:10.1016/j.jalz.2019.04.001

articleAlzheimer s & DementiaJun 1, 2019BRONZE OA

Duration of preclinical, prodromal, and dementia stages of Alzheimer's disease in relation to age, sex, and APOE genotype

LVLisa Vermunt SASietske A.M. Sikkes AVArdo van den Hout RHRon Handels IBIsabelle Bos

University Medical Center · Amsterdam Neuroscience · +30 more institutions

PubMed

Indexed incrossrefpubmed

Abstract

Introduction

We estimated the age-specific duration of the preclinical, prodromal, and dementia stages of Alzheimer's disease (AD) and the influence of sex, setting, apolipoprotein E (APOE) genotype, and cerebrospinal fluid tau on disease duration.

Methods

We performed multistate modeling in a combined sample of 6 cohorts (n = 3268) with death as the end stage and estimated the preclinical, prodromal, and dementia stage duration.

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559

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Authors

24

Topics & keywords

Topics

Keywords

Dementia
Apolipoprotein E
Genotype
Disease
Duration (music)
Psychology
Medicine
Alzheimer's disease

UN Sustainable Development Goals

Good health and well-being

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