m6A-induced lncRNA RP11 triggers the dissemination of colorectal cancer cells via upregulation of Zeb1

Long noncoding RNAs (lncRNAs) have emerged as critical players in cancer progression, but their functions in colorectal cancer (CRC) metastasis have not been systematically clarified. lncRNA expression profiles in matched normal and CRC tissue were checked using microarray analysis. The biological roles of a novel lncRNA, namely RP11-138 J23.1 (RP11), in development of CRC were checked both in vitro and in vivo. Its association with clinical progression of CRC was further analyzed. RP11 was highly expressed in CRC tissues, and its expression increased with CRC stage in patients. RP11 positively regulated the migration, invasion and epithelial mesenchymal transition (EMT) of CRC cells in vitro and enhanced…

• UO
  University of Chicago
• NN
  National Natural Science Foundation of China

  Awards: 81672608, 81672413, 31801197, 81472470, 81673454, 81430041, 81572270
• SY
  Sun Yat-sen University

  Award: 16ykpy09
• CP
  China Postdoctoral Science Foundation
• FR
  Fundamental Research Funds for the Central Universities

  Awards: 16ykpy09, No. 2018