reviewMolecular CancerMay 23, 2019GOLD OA

The role of necroptosis in cancer biology and therapy

YGYitao GongZFZhiyao FanGLGuopei LuoCYChao YangQHQiuyi Huang

Fudan University Shanghai Cancer Center · Shanghai Medical College of Fudan University · +1 more institution

PubMed
Indexed incrossrefdoajpubmed

Abstract

Apoptosis resistance is to a large extent a major obstacle leading to chemotherapy failure during cancer treatment. Bypassing the apoptotic pathway to induce cancer cell death is considered to be a promising approach to overcoming this problem. Necroptosis is a regulated necrotic cell death modality in a caspase-independent fashion and is mainly mediated by Receptor-Interacting Protein 1 (RIP1), RIP3, and Mixed Lineage Kinase Domain-Like (MLKL). Necroptosis serves as an alternative mode of programmed cell death overcoming apoptosis resistance and may trigger and amplify antitumor immunity in cancer therapy.The role of necroptosis in cancer is complicated. The expression of key regulators of the necroptotic…

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1,072
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Authors

11

Topics & keywords

Topics
Keywords
  • Necroptosis
  • Biology
  • Cancer therapy
  • Cancer
  • Cancer research
  • Computational biology
  • Bioinformatics
  • Apoptosis
UN Sustainable Development Goals
  • Good health and well-being
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