Longitudinal multi-omics of host–microbe dynamics in prediabetes

Type 2 diabetes mellitus (T2D) is a growing health problem, but little is known about its early disease stages, its effects on biological processes or the transition to clinical T2D. To understand the earliest stages of T2D better, we obtained samples from 106 healthy individuals and individuals with prediabetes over approximately four years and performed deep profiling of transcriptomes, metabolomes, cytokines, and proteomes, as well as changes in the microbiome. This rich longitudinal data set revealed many insights: first, healthy profiles are distinct among individuals while displaying diverse patterns of intra- and/or inter-personal variability. Second, extensive host and microbial changes occur during…

• SN
  Schweizerischer Nationalfonds zur Förderung der Wissenschaftlichen Forschung
• NI
  National Institutes of Health

  Awards: R01HG008164, U54DK102556, S10OD020141, K08 ES028825, P30DK116074, TR001085, UL1 TR001085