Dynamic Modulation of the Gut Microbiota and Metabolome by Bacteriophages in a Mouse Model
Harvard University · Center for Systems Biology · +1 more institution
Abstract
The human gut microbiome is comprised of densely colonizing microorganisms including bacteriophages, which are in dynamic interaction with each other and the mammalian host. To address how bacteriophages impact bacterial communities in the gut, we investigated the dynamic effects of phages on a model microbiome. Gnotobiotic mice were colonized with defined human gut commensal bacteria and subjected to predation by cognate lytic phages. We found that phage predation not only directly impacts susceptible bacteria but also leads to cascading effects on other bacterial species via interbacterial interactions. Metabolomic profiling revealed that shifts in the microbiome caused by phage predation have a direct…
Citation impact
- FWCI
- 23.24
- Percentile
- 100%
- References
- 68
Authors
8- BBBryan B. HsuCorresponding
Harvard University, Center for Systems Biology
- TETravis E. Gibson
Brigham and Women's Hospital, Harvard University
- VYVladimir Yeliseyev
Brigham and Women's Hospital, Harvard University
- QLQing Liu
Brigham and Women's Hospital, Harvard University
- LLLorena Lyon
Harvard University, Center for Systems Biology
Topics & keywords
- Metabolome
- Biology
- Gut flora
- Microbiology
- Computational biology
- Metabolomics
- Cell biology
- Bioinformatics