Cancer modeling meets human organoid technology

Organoids are microscopic self-organizing, three-dimensional structures that are grown from stem cells in vitro. They recapitulate many structural and functional aspects of their in vivo counterpart organs. This versatile technology has led to the development of many novel human cancer models. It is now possible to create indefinitely expanding organoids starting from tumor tissue of individuals suffering from a range of carcinomas. Alternatively, CRISPR-based gene modification allows the engineering of organoid models of cancer through the introduction of any combination of cancer gene alterations to normal organoids. When combined with immune cells and fibroblasts, tumor organoids become models for the…

• LF
  Lustgarten Foundation
• NH
  Northwell Health
• NI
  National Institutes of Health
• SU
  Stand Up To Cancer
• ER
  European Research Council

  Award: EU-ERC-670133 Organoid
• NC
  National Cancer Institute

  Awards: 5P50CA101955-07, U01CA210240-01A1, NIH 5P30CA45508-29, P20CA192996-03, 1R01CA188134-01