The Network of Cancer Genes (NCG): a comprehensive catalogue of known and candidate cancer genes from cancer sequencing screens
King's College London · The Francis Crick Institute
Abstract
The Network of Cancer Genes (NCG) is a manually curated repository of 2372 genes whose somatic modifications have known or predicted cancer driver roles. These genes were collected from 275 publications, including two sources of known cancer genes and 273 cancer sequencing screens of more than 100 cancer types from 34,905 cancer donors and multiple primary sites. This represents a more than 1.5-fold content increase compared to the previous version. NCG also annotates properties of cancer genes, such as duplicability, evolutionary origin, RNA and protein expression, miRNA and protein interactions, and protein function and essentiality. NCG is accessible at http://ncg.kcl.ac.uk/ .
Citation impact
- FWCI
- 31.37
- Percentile
- 100%
- References
- 75
Authors
9- DRDimitra RepanaCorresponding
King's College London, The Francis Crick Institute
- JNJoel Nulsen
King's College London, The Francis Crick Institute
- LDLisa Dreßler
King's College London, The Francis Crick Institute
- MBMichele Bortolomeazzi
King's College London, The Francis Crick Institute
- SKSanthilata Kuppili Venkata
King's College London, The Francis Crick Institute
Topics & keywords
- Biology
- Gene
- Cancer
- Genetics
- Computational biology
- microRNA
- Cancer cell
- Human genetics