reviewAntioxidants and Redox SignalingJun 20, 2019HYBRID OA

Metabolic Responses to Reductive Stress

WXWusheng XiaoJLJoseph Loscalzo

Brigham and Women's Hospital · Harvard University

PubMed
Indexed incrossrefpubmed

Abstract

Significance: Reducing equivalents (NAD(P)H and glutathione [GSH]) are essential for maintaining cellular redox homeostasis and for modulating cellular metabolism. Reductive stress induced by excessive levels of reduced NAD + (NADH), reduced NADP + (NADPH), and GSH is as harmful as oxidative stress and is implicated in many pathological processes. Recent Advances: Reductive stress broadens our view of the importance of cellular redox homeostasis and the influences of an imbalanced redox niche on biological functions, including cell metabolism. Critical Issues: The distribution of cellular NAD(H), NADP(H), and GSH/GSH disulfide is highly compartmentalized. Understanding how cells coordinate different pools of…

Citation impact

440
total citations
FWCI
12.30
Percentile
100%
References
121
Citations per year

Authors

2

Topics & keywords

Topics
Keywords
  • NAD+ kinase
  • Oxidative stress
  • Glutathione
  • Redox
  • Biochemistry
  • Metabolism
  • Cell metabolism
  • Homeostasis
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