Adjuvant Chemotherapy plus Radiation for Locally Advanced Endometrial Cancer
NRG Oncology · University of Kentucky · +13 more institutions
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Abstract
Background
Stage III or IVA endometrial cancer carries a significant risk of systemic and locoregional recurrence.
Methods
In this randomized phase 3 trial, we tested whether 6 months of platinum-based chemotherapy plus radiation therapy (chemoradiotherapy) is associated with longer relapse-free survival (primary end point) than six cycles of combination chemotherapy alone in patients with stage III or IVA endometrial carcinoma. Secondary end points included overall survival, acute and chronic toxic effects, and quality of life.
Citation impact
462
total citations
- FWCI
- 46.83
- Percentile
- 100%
- References
- 37
Citations per year
Authors
18Topics & keywords
Topics
Keywords
- Endometrial cancer
- Adjuvant
- Medicine
- Oncology
- Internal medicine
- Radiation therapy
- Chemotherapy
- Cancer
UN Sustainable Development Goals
- Good health and well-being
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