Immunogenic cell death in cancer therapy: Present and emerging inducers
Shanghai Jiao Tong University · Shanghai Cancer Institute · +2 more institutions
Abstract
In the tumour microenvironment (TME), immunogenic cell death (ICD) plays a major role in stimulating the dysfunctional antitumour immune system. Chronic exposure of damage-associated molecular patterns (DAMPs) attracts receptors and ligands on dendritic cells (DCs) and activates immature DCs to transition to a mature phenotype, which promotes the processing of phagocytic cargo in DCs and accelerates the engulfment of antigenic components by DCs. Consequently, via antigen presentation, DCs stimulate specific T cell responses that kill more cancer cells. The induction of ICD eventually results in long-lasting protective antitumour immunity. Through the exploration of ICD inducers, recent studies have shown that…
Citation impact
- FWCI
- 28.08
- Percentile
- 100%
- References
- 86
Authors
6- JZJingyi Zhou
Shanghai Jiao Tong University, Shanghai Cancer Institute, Shanghai First People's Hospital, Henan Medical University
- GWGangyang Wang
Shanghai Jiao Tong University, Shanghai Cancer Institute, Shanghai First People's Hospital
- YCYinze Chen
Henan Medical University
- HWHongxia Wang
Shanghai Jiao Tong University, Shanghai First People's Hospital
- YHYingqi Hua
Shanghai Jiao Tong University, Shanghai Cancer Institute, Shanghai First People's Hospital
Topics & keywords
- Immunogenic cell death
- Immune system
- Programmed cell death
- Antigen
- Antigen presentation
- Biology
- Tumor microenvironment
- Dendritic cell
- Good health and well-being