Body mass index and body composition in relation to 14 cardiovascular conditions in UK Biobank: a Mendelian randomization study
Uppsala University · Karolinska Institutet · +4 more institutions
Abstract
AIMS: The causal role of adiposity for several cardiovascular diseases (CVDs) is unclear. Our primary aim was to apply the Mendelian randomization design to investigate the associations of body mass index (BMI) with 13 CVDs and arterial hypertension. We also assessed the roles of fat mass and fat-free mass on the same outcomes. METHODS AND RESULTS: Single-nucleotide polymorphisms associated with BMI and fat mass and fat-free mass indices were used as instrumental variables to estimate the associations with the cardiovascular conditions among 367 703 UK Biobank participants. After correcting for multiple testing, genetically predicted BMI was significantly positively associated with eight outcomes, including…
Citation impact
- FWCI
- 39.22
- Percentile
- 100%
- References
- 32
Authors
5- SCSusanna C. LarssonCorresponding
Uppsala University, Karolinska Institutet
- MBMagnus Bäck
Karolinska University Hospital, Karolinska Institutet
- JMJessica M. B. Rees
University of Cambridge, University of Edinburgh
- AMAmy M. Mason
University of Cambridge
- SBStephen Burgess
University of Cambridge, MRC Biostatistics Unit
Topics & keywords
- Mendelian randomization
- Medicine
- Biobank
- Body mass index
- Relation (database)
- Randomization
- Gerontology
- Internal medicine
- Good health and well-being