Estimation of brain age delta from brain imaging

It is of increasing interest to study "brain age" - the apparent age of a subject, as inferred from brain imaging data. The difference between brain age and actual age (the "delta") is typically computed, reflecting deviation from the population norm. This therefore may reflect accelerated aging (positive delta) or resilience (negative delta) and has been found to be a useful correlate with factors such as disease and cognitive decline. However, although there has been a range of methods proposed for estimating brain age, there has been little study of the optimal ways of computing the delta. In this technical note we describe problems with the most common current approach, and present potential improvements.…

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  Wellcome

  Awards: 203139/Z/16/Z, 098369/Z/12/Z