Ruminococcus gnavus  , a member of the human gut microbiome associated with Crohn’s disease, produces an inflammatory polysaccharide

Henke, Matthew T.; Kenny, Douglas J.; Cassilly, Chelsi D.; Vlamakis, Hera; Xavier, Ramnik J.; Clardy, Jon

doi:10.1073/pnas.1904099116

articleProceedings of the National Academy of SciencesJun 10, 2019GREEN OA

Ruminococcus gnavus , a member of the human gut microbiome associated with Crohn’s disease, produces an inflammatory polysaccharide

MTMatthew T. Henke DJDouglas J. Kenny CDChelsi D. Cassilly HVHera Vlamakis RJRamnik J. Xavier

Harvard University · Broad Institute · +1 more institution

PubMed

Indexed incrossrefpubmed

Abstract

Synthesizes and secretes a complex glucorhamnan polysaccharide with a rhamnose backbone and glucose sidechains. Chemical and spectroscopic studies indicated that the glucorhamnan was largely a repeating unit of five sugars with a linear backbone formed from three rhamnose units and a short sidechain composed of two glucose units. The rhamnose backbone is made from 1,2- and 1,3-linked rhamnose units, and the sidechain has a terminal glucose linked to a 1,6-glucose. This glucorhamnan potently induces inflammatory cytokine (TNFα) secretion by dendritic cells, and TNFα secretion is dependent on toll-like receptor 4 (TLR4). We also identify a putative biosynthetic gene cluster for this molecule, which has the four…

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Topics & keywords

Topics

Keywords

Ruminococcus
Inflammatory bowel disease
Immune system
Microbiome
Disease
Biology
Immunology
Crohn's disease

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