articleCerebral CortexJun 23, 2017BRONZE OA

Local-Global Parcellation of the Human Cerebral Cortex from Intrinsic Functional Connectivity MRI

ASAlexander SchaeferRKRu KongEMEvan M. GordonTOTimothy O. LaumannXZXi‐Nian Zuo

A*STAR-NUS Clinical Imaging Research Centre · National University of Singapore · +11 more institutions

PubMed
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Abstract

A central goal in systems neuroscience is the parcellation of the cerebral cortex into discrete neurobiological "atoms". Resting-state functional magnetic resonance imaging (rs-fMRI) offers the possibility of in vivo human cortical parcellation. Almost all previous parcellations relied on 1 of 2 approaches. The local gradient approach detects abrupt transitions in functional connectivity patterns. These transitions potentially reflect cortical areal boundaries defined by histology or visuotopic fMRI. By contrast, the global similarity approach clusters similar functional connectivity patterns regardless of spatial proximity, resulting in parcels with homogeneous (similar) rs-fMRI signals. Here, we propose a…

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Topics
Keywords
  • Neuroscience
  • Functional connectivity
  • Cerebral cortex
  • Psychology
  • Human brain
  • Brain mapping
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