Conceptualizing mental disorders as deviations from normative functioning

Normative models are a class of emerging statistical techniques useful for understanding the heterogeneous biology underlying psychiatric disorders at the level of the individual participant. Analogous to normative growth charts used in paediatric medicine for plotting child development in terms of height or weight as a function of age, normative models chart variation in clinical cohorts in terms of mappings between quantitative biological measures and clinically relevant variables. An emerging body of literature has demonstrated that such techniques are excellent tools for parsing the heterogeneity in clinical cohorts by providing statistical inferences at the level of the individual participant with respect…

• W
  Wellcome

  Award: 098369/Z/12/Z
• WT
  Wellcome Trust

  Awards: 098369/Z/12/Z, 098369
• NO
  Nederlandse Organisatie voor Wetenschappelijk Onderzoek

  Awards: 864.12.003, 016.156.415, 864.12
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  Cilag