Spatiotemporal dynamics of molecular pathology in amyotrophic lateral sclerosis

Paralysis occurring in amyotrophic lateral sclerosis (ALS) results from denervation of skeletal muscle as a consequence of motor neuron degeneration. Interactions between motor neurons and glia contribute to motor neuron loss, but the spatiotemporal ordering of molecular events that drive these processes in intact spinal tissue remains poorly understood. Here, we use spatial transcriptomics to obtain gene expression measurements of mouse spinal cords over the course of disease, as well as of postmortem tissue from ALS patients, to characterize the underlying molecular mechanisms in ALS. We identify pathway dynamics, distinguish regional differences between microglia and astrocyte populations at early time…

• SF
  Simons Foundation
• AA
  ALS Association

  Award: 15-LGCA-234
• TA
  Target ALS
• TF
  Tow Foundation
• NY
  New York Genome Center
• FH
  Flatiron Health
• KO
  Knut och Alice Wallenbergs Stiftelse

  Award: 2016.0454
• SF
  Science for Life Laboratory