Targeting Early Atherosclerosis: A Focus on Oxidative Stress and Inflammation

Marchio, Patricia; Guerra‐Ojeda, Sol; Vila, José María; Aldasoro, Martı́n; Víctor, Víctor M.; Mauricio, María Dolores

doi:10.1155/2019/8563845

reviewOxidative Medicine and Cellular LongevityJul 1, 2019HYBRID OA

Targeting Early Atherosclerosis: A Focus on Oxidative Stress and Inflammation

PMPatricia Marchio SGSol Guerra‐Ojeda JMJosé María Vila MAMartı́n Aldasoro VMVíctor M. Víctor

Universitat de València · INCLIVA Health Research Institute · +2 more institutions

PubMed

Indexed incrossrefdoajpubmed

Abstract

Atherosclerosis is a chronic vascular inflammatory disease associated to oxidative stress and endothelial dysfunction. Oxidation of low-density lipoprotein (LDL) cholesterol is one of the key factors for the development of atherosclerosis. Nonoxidized LDL have a low affinity for macrophages, so they are not themselves a risk factor. However, lowering LDL levels is a common clinical practice to reduce oxidation and the risk of major events in patients with cardiovascular diseases (CVD). Atherosclerosis starts with dysfunctional changes in the endothelium induced by disturbed shear stress which can lead to endothelial and platelet activation, adhesion of monocytes on the activated endothelium, and…

Citation impact

614

total citations

FWCI: 25.36
Percentile: 100%
References: 327

Citations per year

Authors

6

Topics & keywords

Topics

Keywords

Inflammation
Oxidative stress
Endothelial dysfunction
Proinflammatory cytokine
Endothelium
Chemokine
Immunology
Medicine

UN Sustainable Development Goals

Good health and well-being

No related works found for this paper.