letterCancer ResearchJul 3, 2019Closed access

Stearoyl-CoA Desaturase 1 Protects Ovarian Cancer Cells from Ferroptotic Cell Death

LTLia TesfayBTBibbin T. PaulAKAnna KonstorumZDZhiyong DengAOAnderson O. Cox

UConn Health · Wake Forest University

PubMed
Indexed incrossrefpubmed

Abstract

Abstract Activation of ferroptosis, a recently described mechanism of regulated cell death, dramatically inhibits growth of ovarian cancer cells. Given the importance of lipid metabolism in ferroptosis and the key role of lipids in ovarian cancer, we examined the contribution to ferroptosis of stearoyl-CoA desaturase (SCD1, SCD), an enzyme that catalyzes the rate-limiting step in monounsaturated fatty acid synthesis in ovarian cancer cells. SCD1 was highly expressed in ovarian cancer tissue, cell lines, and a genetic model of ovarian cancer stem cells. Inhibition of SCD1 induced lipid oxidation and cell death. Conversely, overexpression of SCD or exogenous administration of its C16:1 and C18:1 products,…

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Authors

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Topics & keywords

Topics
Keywords
  • Ovarian cancer
  • Programmed cell death
  • Cancer research
  • Apoptosis
  • Cancer cell
  • Cancer
  • Chemistry
  • Fatty acid synthesis
UN Sustainable Development Goals
  • Good health and well-being
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