Prevalence of low-grade inflammation in depression: a systematic review and meta-analysis of CRP levels
University of Cambridge · Hammersmith Hospital · +4 more institutions
Abstract
Peripheral low-grade inflammation in depression is increasingly seen as a therapeutic target. We aimed to establish the prevalence of low-grade inflammation in depression, using different C-reactive protein (CRP) levels, through a systematic literature review and meta-analysis.
We searched the PubMed database from its inception to July 2018, and selected studies that assessed depression using a validated tool/scale, and allowed the calculation of the proportion of patients with low-grade inflammation (CRP >3 mg/L) or elevated CRP (>1 mg/L).
Citation impact
- FWCI
- 20.51
- Percentile
- 100%
- References
- 94
Authors
5- EFEmanuele F. OsimoCorresponding
University of Cambridge, Hammersmith Hospital, Cambridgeshire and Peterborough NHS Foundation Trust, MRC London Institute of Medical Sciences, Imperial College London
- LBLuke Baxter
University of Cambridge
- GLGlyn Lewis
University College London
- PBPeter B. Jones
University of Cambridge, Cambridgeshire and Peterborough NHS Foundation Trust
- GMGolam M. Khandaker
University of Cambridge, Cambridgeshire and Peterborough NHS Foundation Trust
Topics & keywords
- Depression (economics)
- Meta-analysis
- Medicine
- Internal medicine
- Odds ratio
- C-reactive protein
- Inflammation
- Antidepressant
- Good health and well-being