articleAngewandte Chemie International EditionJun 25, 2019Closed access

A Nanozyme with Photo‐Enhanced Dual Enzyme‐Like Activities for Deep Pancreatic Cancer Therapy

SLShanshan LiLSLu ShangBXBolong XuSWShunhao WangKGKai Gu

Beijing University of Chemical Technology · Chinese Academy of Sciences · +3 more institutions

PubMed
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Abstract

Abstract Nanozymes have attracted extensive interest owing to their high stability, low cost and easy preparation, especially in the field of cancer therapy. However, the relatively low catalytic activity of nanozymes in the tumor microenvironment (TME) has limited their applications. Herein, we report a novel nanozyme (PtFe@Fe 3 O 4 ) with dual enzyme‐like activities for highly efficient tumor catalytic therapy. PtFe@Fe 3 O 4 shows the intrinsic photothermal effect as well as photo‐enhanced peroxidase‐like and catalase‐like activities in the acidic TME, thereby effectively killing tumor cells and overcoming the tumor hypoxia. Importantly, a possible photo‐enhanced synergistic catalytic mechanism of PtFe@Fe 3…

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Topics & keywords

Topics
Keywords
  • Photothermal therapy
  • Tumor microenvironment
  • Cancer therapy
  • Catalysis
  • Chemistry
  • Tumor hypoxia
  • Pancreatic cancer
  • Dual role
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