reviewOxidative Medicine and Cellular LongevityJul 14, 2019HYBRID OA

Activators and Inhibitors of NRF2: A Review of Their Potential for Clinical Development

NRNatalia Robledinos-AntónRFRaquel Fernández-GinésGMGina MandaACAntonio Cuadrado

Instituto de Salud Carlos III · Biomedical Research Networking Center on Neurodegenerative Diseases · +3 more institutions

PubMed
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Abstract

The transcription factor NRF2 (nuclear factor erythroid 2-related factor 2) triggers the first line of homeostatic responses against a plethora of environmental or endogenous deviations in redox metabolism, proteostasis, inflammation, etc. Therefore, pharmacological activation of NRF2 is a promising therapeutic approach for several chronic diseases that are underlined by oxidative stress and inflammation, such as neurodegenerative, cardiovascular, and metabolic diseases. A particular case is cancer, where NRF2 confers a survival advantage to constituted tumors, and therefore, NRF2 inhibition is desired. This review describes the electrophilic and nonelectrophilic NRF2 activators with clinical projection in…

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607
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30.08
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100%
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166
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Authors

4

Topics & keywords

Topics
Keywords
  • Proteostasis
  • Inflammation
  • Transcription factor
  • Oxidative stress
  • Endogeny
  • Bioinformatics
  • Cancer
  • Biology
UN Sustainable Development Goals
  • Good health and well-being
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